科研之友
微信
新浪微博
Facebook
分享链接
摘要
A new sulfated holostane glycoside, leucospilotaside B (1), together with the two related structurally known compounds holothurin B-2 (2) and holothurin B (3), was isolated from sea cucumber Holothuria leucospilota collected from the South China Sea. The structure of I was elucidated by spectral analysis (H-1-, C-13-, and 2D-NMR, ESI-MS, and HR-ESI-MS) and chemical methods. The compounds 1-3 possess the same disaccharide moiety, but were different in the side chains of the triterpene aglycone. Compound 1 showed significant cytotoxicities against four human tumor cell lines, HL-60, MOLT-4, A-549, and BEL-7402.
- 出版日期2010
- 单位中国人民解放军第二军医大学; 浙江大学
