Morphological and bioenergetic demands underlying the nnitophagy in post-mitotic neurons: the pink parkin pathway

作者：Amadoro Giuseppina^*; Corsetti Veronica; Florenzano Fulvio; Atlante Anna; Bobba Antonella; Nicolin Vanessa; Nori Stefania L; Calissano Pietro

来源：Frontiers in Aging Neuroscience, 2014, 6: 18.

DOI：10.3389/fnagi.2014.00018

• mitochondria dynamics
• quality control
• mitophagy
• primary neurons
• neurodegenerative diseases

Evidence suggests a striking causal relationship between changes in quality control of neuronal mitochondria and numerous devastating human neurodegenerative diseases, including Parkinson%26apos;s disease, Alzheimer%26apos;s disease, Huntington%26apos;s disease, and amyotrophic lateral sclerosis. Contrary to replicating mammalian cells with a metabolism essentially glycolytic, post-mitotic neurons are distinctive owing to (i) their exclusive energetic dependence from mitochondrial metabolism and (ii) their polarized shape, which entails compartmentalized and distinct energetic needs. Here, we review the recent findings on mitochondrial dynamics and mitophagy in differentiated neurons focusing on how the exceptional characteristics of neuronal populations in their morphology and bioenergetics needs make them quite different to other cells in controlling the intracellular turnover of these organelles.

• 出版日期2014-2-18