Absence of association between Guillain-Barre syndrome hospitalizations and HPV-vaccine

作者：Deceuninck Genevieve; Sauvageau Chantal; Gilca Vladimir; Boulianne Nicole; De Serres Gaston

来源：Expert Review of Vaccines, 2018, 17(1): 99-102.

DOI：10.1080/14760584.2018.1388168

• Guillain-Barre syndrome
• human papilloma virus
• immunization
• safety
• vaccine

Background: In 2008, a school-based human papilloma virus (HPV) vaccination program was implemented in the province of Quebec. Grade 4 girls (9-10 years old) are routinely vaccinated and grade 9 to 12 girls (14-17 years old) were eligible for the catch-up vaccination. Vaccine coverage of the targeted cohorts was estimated at 76-81%. To assess if HPV vaccination is associated with an increase in GBS hospitalisation, we compared the hospitalization rates of GBS in HPV vaccination targeted and non-targeted groups.
Methods: Hospital discharge records with a GBS code as the main diagnosis during the 1999-2014 period were retrieved. Incidence rates according to program eligibility were computed and adjusted relative risk in the targeted groups was estimated by Poisson regression.
Results: The overall incidence rate in the 7 to 17 year-olds was 0.73/100,000 p-y. There was no increase in GBS incidence in HPV vaccination targeted groups (adjusted IRR = 0.81, 95% CI: 0.29-2.26).
Conclusion: No signal of increase GBS hospitalisation incidence in the HPV-vaccine targeted group was detected in the hospitalisation database.

• 出版日期2018