A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support

作者：Li Yangmei; Giulianotti Marc; Houghten Richard A^*

来源：Tetrahedron Letters, 2010, 51(43): 5637-5639.

DOI：10.1016/j.tetlet.2010.08.026

A facile solid-phase synthetic approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives was reported. Functionalized aminomethylphenyl silica gel was used as a 'volatilizable' support. The products were cleaved with 10% HF and were obtained in high yields and purities.

• 出版日期2010-10-27