Association of folic acid receptor alpha in maternal serum with neural tube defects

作者:Celik Ebru*; Karaer Abdullah; Turkcuoglu Ilgin; Turhan Ugur; Gungoren Arif; Taskapan Cagatay; Ozyalin Fatma; Berker Bulent
来源:Journal of Maternal-Fetal and Neonatal Medicine, 2014, 27(11): 1083-1087.
DOI:10.3109/14767058.2013.849239

摘要

Objective: To evaluate whether serum folic receptor alpha levels are changed in women whose previous pregnancies were complicated with neural tube defects (NTDs).
Methods: This was a case-control study that included 41 women as the control group who had previously had at least one healthy pregnancy and 37 women as the study group who had a previous pregnancy complicated with NTDs. Blood samples were obtained from all of the participants six weeks after the termination of pregnancy or delivery of a baby. Serum folate receptor alpha concentrations were analyzed using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.
Results: The mean concentrations of serum folate receptor alpha were significantly lower in the NTD cases compared to those in the control group (p = 0.02). There was no significant difference in mean serum folate titers between the NTD cases and the control group (p = 0.07).
Conclusion: Low serum folic acid receptor alpha levels in the current study did not appear to be a regulatory marker of maternal folate homeostasis per se but rather a factor that contributed to the development of NTDs.

  • 出版日期2014-7

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