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摘要
A simple and sensitive electrochemical method is described for the determination of the cholesterol-reducing drug ezetimibe in aqueous solution. A glassy carbon electrode, modified with multiwalled carbon nanotubes and sodium dodecylsulphate was used as the working electrode. Ezetimibe yields a well-defined anodic peak at the surface of the electrode in an aqueous solution of pH 13. A linear amperometric calibration curve was obtained in the range of 1.2-78 mu M (0.5-32.0 mu g/mL) of ezetimibe, with a sensitivity of 88.6 nA/mu M and a detection limit of 300nM (0.12 mu g/mL). The sensor was applied successfully to the determination of ezetimibe in pharmaceutical preparations.
- 出版日期2010
