Androgen Receptor Increases CD133 Expression and Progenitor-Like Population That Associate With Cisplatin Resistance in Endometrial Cancer Cell Line

作者：Chen Lumin; Chang Wei Chun; Hung Yao Ching; Chang Ying Yi; Bao Bo Yin; Huang Hsin Ching; Chung Wei Min; Shyr Chih Rong; Ma Wen Lung^*

来源：Reproductive Sciences, 2014, 21(3): 386-394.

DOI：10.1177/1933719113497281

• AR
• endometrial cancer
• cancer stem
• progenitor cells
• cisplatin resistance
• side population cell

Endometrial cancer (EMC) is a sex steroid hormone-related female malignancy. Androgen and androgen receptor (androgen/AR) signals have been implicated in EMC progression. Cancer stem/progenitor cells (CSPCs) are suspected to link to chemoresistance in patients with EMC. In this study, we examined the androgen/AR roles in cisplatin resistance and CSPC population. We found AR expression increased naive EMC side population, CSPC population, cell migration, and epithelial-mesenchymal transition. Meanwhile, it decreased cisplatin cytotoxic effect on EMC cells. Collaterally, endogenous AR expressions in EMC cells were upregulated in the cisplatin-resisting state. Moreover, AR expression could further enhance CD133 expression, CSPC-related markers, and drug-resistance gene messenger RNA expression in EMC cells. Finally, the AR-associated gene expression might go through indirect regulation. This is the first report revealing AR function on EMC cells%26apos; CSPC and cisplatin resistance.

• 出版日期2014-3
• 单位中国医科大学