Near-infrared cholecystocholangiography with direct intragallbladder indocyanine green injection: preliminary clinical results

作者：Liu Yu Yin; Liao Chien Hung; Diana Michele^*; Wang Shang Yu; Kong Seong Ho; Yeh Chun Nan; Dallemagne Bernard; Marescaux Jacques; Yeh Ta Sen^*

来源：Surgical Endoscopy and Other Interventional Techniques, 2018, 32(3): 1506-1514.

DOI：10.1007/s00464-017-5838-9

• Near-infrared cholangiography
• Direct intragallbladder
• Fluorophore injection

Background Near-infrared (NIR) fluorescence cholangiography by systemic administration of indocyanine green (ICG) enhances the visualization of the biliary tree anatomy. However, the simultaneous enhancement of liver parenchyma can disturb the visualization of critical details. We herein proposed a new technique of NIR cholecysto-cholangiography by intragallbladder ICG injection to increase the safety during laparoscopic cholecystectomy.
Methods A total of 46 patients scheduled for laparoscopic cholecystectomy for symptomatic lithiasis (n = 21) or cholecystitis (n = 25) were enrolled. A fluorescence cholangiography by direct gallbladder injection of ICG was performed in all cases. Of them, the ICG was injected through a previously placed percutaneous transhepatic gallbladder drainage catheter (n = 18) or by intraoperative, percutaneous needle puncture of the gallbladder (n = 28). Visualization of biliary structures, including the cystic duct (CD), the common bile and hepatic ducts (CBD and CHD), the gallbladder neck, and the Hartmann's pouch (HP), was performed using White Light (served as control modality) and by NIR enhancement.
Results Cholecystocholangiography provided a significantly higher rate of visualization of the CD in case of cholecystitis with mild adhesions, and an improved visualization of the HP, CBD, and CHD in case of severe inflammation, when compared to White Light observation. There were no benefits of NIR in case of non-inflamed lithiasis.
Conclusions Clinical translation of NIR cholecysto-cholangiography has been successful with a noise-free visualization of biliary anatomy. It can be considered in difficult cases to increase the safety of laparoscopic cholecystectomy.

• 出版日期2018-3
• 单位长春大学