Angiotensin-converting enzyme gene insertion/deletion polymorphisms and the susceptibility to allergic rhinitis

作者：Guo, M.; Ma, J.; Han, Y.; Lu, L.^*

来源：Allergologia et Immunopathologia, 2014, 42(6): 568-572.

DOI：10.1016/j.aller.2013.09.008

• Allergic rhinitis
• Polymorphism
• Angiotensin
• converting enzyme
• Meta-analysis

Background: Angiotensin-converting enzyme (ACE) gene I /D polymorphism might be linked to the risk of the allergic rhinitis (AR).
Objective: In the present study, we assessed the association of ACE gene I/D polymorphisms with AR susceptibility using a meta-analysis.
Materials and methods: We carried out a retrieval of studies and included the eligible studies if they met the criteria. After the data extraction, the Stata software was used to analyse the genotype frequencies.
Results: In total, five studies with 561 patients and 603 controls were included. However, the genotype distribution among the control of one study was not consistent with the Hardy-Weinberg equilibrium. After pooling all studies, the results indicated an association between ACE gene I/D polymorphism and AR risk in the overall analysis (II vs. others: OR= 0.70, 95% CI = 0.54-0.92, P=0.010; D vs. I: OR = 1.29, 95% CI =1.08-1.54, P=0.005). In the further analysis of the East Asians, no association between ACE gene I/D polymorphism and AR risk was observed.
Conclusion: ACE gene I/D polymorphisms were not associated with the risk of AR in East Asians. These results need to be confirmed in the following studies.

• 出版日期2014-12
• 单位昆明医科大学