Apoptosis in animal models of virus-induced disease

作者:Clarke Penny*; Tyler Kenneth L
来源:Nature Reviews Microbiology, 2009, 7(2): 144-155.
DOI:10.1038/nrmicro2071

摘要

Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes substantial morbidity and mortality. Although virus-induced apoptosis is well characterized in individual cells in cell culture, virus-induced apoptosis in vivo and the role of apoptosis in virus-induced disease is not well established. This Review focuses on animal models of virus-induced diseases of the central nervous system, heart and liver that provide insights into the role of apoptosis in pathogenesis, the pathways involved and the potential therapeutic implications.

  • 出版日期2009-2