Ultrasensitive and facile electrochemical deoxyribonucleic acid biosensor based on the conformational change of the recognition interface

作者：Chen, Wei^*; Liu, Yin-Huan; Li, Hong-Na; Liu, Ai-Lin; Lin, Xin-Hua; Chen, Yuan-Zhong

来源：Analytica Chimica Acta, 2012, 748: 89-94.

DOI：10.1016/j.aca.2012.08.046

• Biosensor
• Electrochemical impedance spectroscopy
• Deoxyribonucleic acid
• Conformational change
• Recognition interface

An ultrasensitive electrochemical impedance spectroscopic deoxyribonucleic acid biosensor has been developed based on the conformational change of the deoxyribonucleic acid recognition interface with lodging probes. Pairing process leads to desorption of deoxyribonucleic acid bases from the gold surface, leading to a significant change of the interfacial conformation and the charge transfer resistance. Remarkably low detection limits down to 40 fM are thus obtained without any additional amplification step.

• 出版日期2012-10-20
• 单位福建医科大学