A proton-responsive ensemble using mesocellular foam supports capped with N, O-carboxymethyl chitosan for controlled release of bioactive proteins

作者：Gan, Qi; Zhu, Jiaoyang; Yuan, Yuan^*; Liu, Honglai; Zhu, Yihua; Liu, Changsheng

来源：Journal of Materials Chemistry B, 2015, 3(11): 2281-2285.

DOI：10.1039/c5tb00219b

• MESOPOROUS SILICA NANOPARTICLES
• DRUG-DELIVERY SYSTEM
• GENE DELIVERY
• ORAL DELIVERY
• INSULIN
• NANOHYBRIDS
• HYDROGELS
• CATALYSTS
• CALCIUM

A novel pH-responsive mesocellular foam-based nanocarrier was fabricated by the covalent assembly of a water-soluble N, O-carboxymethyl chitosan via the crosslinking of GPTMS. The delivery systems show excellent protein loading with programmable release in an acid environment. Moreover, the released proteins still preserve their conformational and biological activity.

• 出版日期2015
• 单位生物反应器工程国家重点实验室; 华东理工大学; 化学工程联合国家重点实验室