Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis

作者：Gordon Katherine; Miteva Maria; Torchia Daniele^*; Romanelli Paolo

来源：Cutaneous and Ocular Toxicology, 2012, 31(4): 338-340.

DOI：10.3109/15569527.2011.647180

• Allopurinol
• palisaded neutrophilic and granulomatous dermatitis
• drug reaction

We describe a 64-year-old man with past chronic myeloid leukemia. Palisading neutrophilic granulomatous dermatitis of the hands was diagnosed and related to recent allopurinol intake. Allopurinol is known to rarely cause granulomatous reactions, but this appears to be the first case of palisading neutrophilic granulomatous dermatitis induction. Possible mechanisms include immune complex deposition, an immune response directed against the metabolites of allopurinol, or allopurinol hypersensitivity exclusively localized to the skin.

• 出版日期2012-12