A Diels-Alder reaction conducted within the parameters of aqueous organocatalysis: still just smoke and mirrors

作者：Stowe G Neil; Janda Kim D^*

来源：Tetrahedron Letters, 2011, 52(17): 2085-2087.

DOI：10.1016/j.tetlet.2010.10.134

• Nornicotine
• Organocatalysis
• Diels-Alder
• Aqueous

Conducting reactions using water as solvent is a highly prized goal for the organic chemist. Based upon recent literature and our continuing interest in the field of aqueous organocatalysis, we tested the scope of an enamine based Diels-Alder reaction using (+/-)-nornicotine, proline, and a proline derivative as aqueous organocatalysts. Unfortunately, none of the examined catalysts under aqueous conditions proved useful, leaving the aqueous Diels-Alder reaction as an elusive goal.

• 出版日期2011-4-27