Design, Synthesis, and Photochemistry of Modular Caging Groups for Photoreleasable Nucleotides

作者：Furuta Toshiaki^*; Manabe Kaori; Teraoka Aoi; Murakoshi Kanako; Ohtsubo Ai; Suzuki Akinobu

来源：Organic Letters, 2012, 14(24): 6182-6185.

DOI：10.1021/ol3029093

A modular approach to preparing caged nucleotides having additional properties has been achieved. The modular caging agent includes three components: an amine reactive NHS ester moiety, a photoactive Bhc group, and tosylhydrazone as a precursor of the diazomethyl group. Various amines including biotin and an Arg-Gly-Asp (RGD) peptide were introduced into the key intermediate via amide linkage. The Bio-Bhc-diazo thus synthesized enables the preparation of a photoreleasable siRNA with additional properties.

• 出版日期2012-12-21