Limbic Encephalitis Associated with Sjogren's Syndrome: Report of Three Cases

作者：Coban Arzu^*; Ozyurt Selen; Meric Kaan; Misirli Handan; Tuzun Erdem; Turkoglu Recai

来源：Internal Medicine, 2016, 55(16): 2285-2289.

DOI：10.2169/internalmedicine.55.6222

• limbic encephalitis
• autoimmune encephalitis
• Sjogren's syndrome
• motor neuropathy
• immunotherapy

Sjogren's syndrome (SS) may be complicated by neurological manifestations. We herein report three women (age range 26-60 years old) who all presented with limbic encephalitis (LE) as the predominant clinical feature 3 months to 15 years after the diagnosis of SS. The 26-year-old patient also developed acute motor axonal neuropathy one week after autoimmune encephalitis. All three patients showed contrast-enhanced MRI lesions and inflammatory cerebrospinal fluid findings, while not displaying any anti-neuronal antibodies and showing a remarkable response to immunotherapy. SS is often overlooked when the symptoms are mild. Therefore, in LE cases with no identifiable cause, serological screening for rheumatologic disorders is recommended.

• 出版日期2016