Maternal high-fat diet is associated with impaired fetal lung development

作者：Mayor Reina S; Finch Katelyn E; Zehr Jordan; Morselli Eugenia; Neinast Michael D; Frank Aaron P; Hahner Lisa D; Wang Jason; Rakheja Dinesh; Palmer Biff F; Rosenfeld Charles R; Savani Rashmin C; Clegg Deborah J^*

来源：American Journal of Physiology - Lung Cellular and Molecular Physiology, 2015, 309(4): L360-L368.

DOI：10.1152/ajplung.00105.2015

• respiratory distress syndrome
• intrauterine growth restriction
• fetal growth restriction
• placental inflammation
• chorioamnionitis

Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.

• 出版日期2015-8-15