Emergence of Zaire Ebola Virus Disease in Guinea

作者：Baize, Sylvain; Pannetier, Delphine; Oestereich, Lisa; Rieger, Toni; Koivogui, Lamine; Magassouba, N'Faly; Soropogui, Barre; Sow, Mamadou Saliou; Keita, Sakoba; De Clerck, Hilde; Tiffany, Amanda; Dominguez, Gemma; Loua, Mathieu; Traore, Alexis; Kolie, Moussa; Malano, Emmanuel Roland; Heleze, Emmanuel; Bocquin, Anne; Mely, Stephane; Raoul, Herve; Caro, Valerie; Cadar, Daniel; Gabriel, Martin; Pahlmann, Meike; Tappe, Dennis; Schmidt-Chanasit, Jonas; Impouma, Benido; Diallo, Abdoul Karim

来源：New England Journal of Medicine, 2014, 371(15): 1418-1425.

DOI：10.1056/NEJMoa1404505

• LASSA-VIRUS
• FILOVIRUSES
• INFECTION
• ASSAY

In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.

• 出版日期2014-10-9