A green one-pot synthesis of N-alkyl-2-(2-oxoazepan-1-yl)-2-arylacetamide derivatives via an Ugi four-center, three-component reaction in water

作者：Rasouli Mohammad Ali; Mandavi Mohammad; Ranjbar Parviz Rashidi; Saeedi Mina; Shafiee Abbas; Foroumadi Alireza^*

来源：Tetrahedron Letters, 2012, 53(52): 7088-7092.

DOI：10.1016/j.tetlet.2012.10.075

• N-Alkyl-2-(2-oxoazepan-1-yl)-2-arylacetamides
• Multicomponent reactions (MCRs)
• Heterocycles
• Azepan-2-ones

This work describes a green and efficient one-pot synthesis of N-alkyl-2-(2-oxoazepan-1-yl)-2-arylacetamide derivatives via an Ugi four-center, three-component reaction of 6-aminohexanoic acid, aromatic aldehydes, and isocyanide derivatives in water under reflux conditions in the absence of a catalyst.

• 出版日期2012-12-26