Histone Deacetylase 6 Regulates Estrogen Receptor alpha in Uterine Leiomyoma

作者：Wei Lin Hung; Torng Pao Ling; Hsiao Sheng Mou; Jeng Yung Ming; Chen Min Wei; Chen Chi An^*

来源：Reproductive Sciences, 2011, 18(8): 755-762.

DOI：10.1177/1933719111398147

• uterine
• leiomyoma
• histone deacetylase 6
• estrogen receptor
• proliferation
• degradation

Histone deacetylase 6 (HDAC) 6 is a regulatory factor in the endocrine traffic network that controls growth factor receptor stability. Histone deacetylase 6 expression and its pathogenic role in the uterine leiomyoma have not been studied. Here, we demonstrated that there was a consistent pattern of increasing HDAC6 and estrogen receptor (ER) alpha expression in leiomyoma samples. For all individual cases, expression of HDAC6 in the normal myometrium or leiomyoma positively correlated with ER alpha expression. The spearman's rho (rho) was .53 (P = .008) between HDAC6 and ER alpha in normal myometrium and, more significantly, the spearman rho was .80 (P < .001) between HDAC6 and ER alpha in leiomyoma. In ELT-3 leiomyoma cells, silencing HDAC6 expression substantially reduced ER alpha expression, lowered estrogen response, and inhibited ELT-3 cell growth. Our results, taken together, are the first to provide experimental evidence suggesting that HDAC6 may be an essential molecular therapeutic target in controlling leiomyoma growth.

• 出版日期2011-8