Drug-induced oedema Pathophysiology, diagnosis and management

作者：Schindler C^*; Schellong S M

来源：Phlebologie, 2009, 38(1): 33-41.

• Drug-induced oedema
• vasodilators
• calcium channel blockers
• loop-diuretics
• ACE-inhibitors
• AT(1)-receptor-blockers
• glitazones
• pathophysiology
• treatment strategies

Besides more classical aetiologies for oedema such as heart failure, liver cirrhosis, nephrotic syndrome and chronic venous insufficiency, in practice we increasingly observe iatrogenic or drug-induced oedema as adverse events. Many drugs have the potential to cause oedema or to worsen pre-existing oedema prior to the initiation of drug therapy. Drug-induced oedema is frequently caused by calcium-channel-blockers of the dihydropyridine-type but can also be caused by dihydralazine and minoxidil which are less frequently prescribed. Other drugs which may support the formation of oedema are diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), ACE-inhibitors or AT(1)-receptor-antagonists (angioedema) and thiazolidinediones/glitazones which are used as oral anti-diabetics.
This review focuses on drug-induced oedema, pathophysiological considerations and potential treatment and management strategies from a clinical-pharmacological perspective.

• 出版日期2009-2