Asymmetric hydrogenation of acetophenone catalyzed by cinchonidine stabilized Ir/SiO2

作者：Yang ChaoFen; Jiang HeYan; Feng Jian; Fu HaiYan; Li RuiXiang; Chen Hua^*; Li XianJun

来源：Journal of Molecular Catalysis A: Chemical , 2009, 300(1-2): 98-102.

DOI：10.1016/j.molcata.2008.10.041

• Supported iridium catalyst
• Stabilizer
• Heterogeneous asymmetric hydrogenation
• (1S,2S)-DPEN

A series of silica (SiO2) supported iridium catalysts stabilized by cinchona alkaloids was prepared and applied in the heterogeneous asymmetric hydrogenation of acetophenone. Cinchona alkaloids exhibited a marked ability to stabilize and disperse the Ir particles. In the presence of (1S,2S)-diphenylethylenediamine ((1S,2S)-DPEN)) as chiral modifier, the cinchonidine (CD) stabilized catalyst 5%Ir/2CD-SiO2 exhibited excellent catalytic performance in the asymmetric hydrogenation of acetophenone in MeOH. Under the optimum conditions, the ee value of (R)-phenylethanol achieved 79.8% and no other product was produced, a higher enantioselectivity than that reported up to now for acetophenone hydrogenation catalyzed by the supported metal catalysts modified by chiral reagents. In particular, a synergistic effect between (1S,2S)-DPEN and CD was observed, which significantly accelerated the reaction rate and enhanced the enantioselectivity. The catalyst can be reused several times without a significant loss of activity and enantioselectivity.

• 出版日期2009-3-2
• 单位四川大学