Antihistaminic and cardiorespiratory effects of diphenhydramine hydrochloride in anesthetized dogs undergoing excision of mast cell tumors

作者：Sanchez Andrea; Valverde Alexander^*; Sinclair Melissa; Mosley Cornelia; Singh Ameet; Mutsaers Anthony J; Hanna Brad; Johnson Ron; Gu Yu; Beaudoin Kimble Michelle

来源：Journal of the American Veterinary Medical Association, 2017, 251(7): 804-813.

DOI：10.2460/javma.251.7.804

OBJECTIVE
To evaluate the effects of IV diphenhydramine hydrochloride administration on cardiorespiratory variables in anesthetized dogs undergoing mast cell tumor (MCT) excision.
DESIGN
Randomized, blinded clinical trial.
ANIMALS
16 client-owned dogs with MCTs.
PROCEDURES
In a standardized isoflurane anesthesia session that included mechanical ventilation, dogs received diphenhydramine hydrochloride (1 mg/kg [0.45 mg/lb], IV; n = 8) or an equivalent volume of saline (0.9% NaCl) solution (IV; control treatment; 8) 10 minutes after induction. Cardiorespiratory variables were recorded throughout anesthesia and MCT excision, and blood samples for determination of plasma diphenhydramine and histamine concentrations were collected prior to premedication (baseline), throughout anesthesia, and 2 hours after extubation.
RESULTS
Cardiorespiratory values in both treatment groups were acceptable for anesthetized dogs. Mean +/- SD diastolic arterial blood pressure was significantly lower in the diphenhydramine versus control group during tumor dissection (52 +/- 10 mm Hg vs 62 +/- 9 mm Hg) and surgical closure (51 +/- 10 mm Hg vs 65 +/- 9 mm Hg). Mean arterial blood pressure was significantly lower in the diphenhydramine versus control group during surgical closure (65 +/- 12 mm Hg vs 78 +/- 11 mm Hg), despite a higher cardiac index value. Plasma histamine concentrations were nonsignificantly higher than baseline during maximal manipulation of the tumor and surgical preparation in the diphenhydramine group and during surgical dissection in the control group.
CONCLUSIONS AND CLINICAL RELEVANCE
IV administration of diphenhydramine prior to MCT excision had no clear clinical cardiorespiratory benefits over placebo in isoflurane-anesthetized dogs.

• 出版日期2017-10-1