A comparative molecular dynamics study on thermostability of human and chicken prion proteins

作者：Ji Hong Fang; Zhang Hong Yu^*

来源：Biochemical and Biophysical Research Communications, 2007, 359(3): 790-794.

DOI：10.1016/j.bbrc.2007.05.194

• prion protein
• molecular dynamics simulation
• salt bridge
• unfolding
• ensemble

To compare the thermostabilities of human and chicken normal cellular prion proteins (HuPrP(C) and CkPrP(C)), molecular dynamics (MD) simulations were performed for both proteins at an ensemble level (10 parallel simulations at 400 K and 5 parallel simulations at 300 K as a control). It is found that the thermostability of HuPrP(C) is comparable with that of CkPrP(C), which implicates that the non-occurrence of prion diseases in non-mammals cannot be completely attributed to the thermodynamic properties of non-mammalian PrPC.

• 出版日期2007-8-3
• 单位山东理工大学; 上海生物信息技术研究中心