All natural cellulose acetate-Lemongrass essential oil antimicrobial nanocapsules

作者：Liakos Ioannis L; D' autilia Francesca; Garzoni Alice; Bonferoni Cristina; Scarpellini Alice; Brunetti Virgilio; Carzino Riccardo; Bianchini Paolo; Pompa Pier Paolo; Athanassiou Athanassia

来源：International Journal of Pharmaceutics, 2016, 510(2): 508-515.

DOI：10.1016/j.ijpharm.2016.01.060

• Nanocapsules
• Nanoparticles
• Antimicrobial
• Essential oils
• Drug delivery
• Nano-pharmaceutics
• Cellulose acetate
• Escherichia coli
• Staphylococcus aureus
• Lemongrass oil
• Bio-adhesion

Nanocapsules and nanoparticles play an essential role in the delivery of pharmaceutical agents in modern era, since they can be delivered in specific tissues and cells. Natural polymers, such as cellulose acetate, are becoming very important due to their availability, biocompatibility, absence of toxicity and biodegradability. In parallel, essential oils are having continuous growth in biomedical applications due to the inherent active compounds that they contain. A characteristic example is lemongrass oil that has exceptional antimicrobial properties. In this work, nanocapsules of cellulose acetate with lemongrass oil were developed with the solvent/anti-solvent method with resulting diameter tailored between 95 and 185 nm. Various physico-chemical and surface analysis techniques were employed to investigate the formation of the nanocapsules. These all-natural nanocapsules found to well bioadhere to mucous membranes and to have very good antimicrobial properties at little concentrations against Escherichia coli and Staphylococcus aureus.

• 出版日期2016-8-30