Novel antifungal defensins from Nigella sativa L. seeds

作者：Rogozhin Eugene A^*; Oshchepkova Yulia I; Odintsova Tatyiana I; Khadeeva Natalia V; Veshkurova Olga N; Egorov Tsezi A; Grishin Eugene V; Salikhov Shavkat I

来源：Plant Physiology and Biochemistry, 2011, 49(2): 131-137.

DOI：10.1016/j.plaphy.2010.10.008

• Nigella sativa
• Antimicrobial peptide
• Defensin
• Antifungal activity
• Antibacterial activity

From seeds of Nigella sativa L (Ranunculaceae), an endemic plant of Uzbekistan, two novel defensins named Ns-D1 and Ns-D2, were isolated and sequenced. The peptides differ by a single amino acid residue and show high sequence similarity to Raphanus sativus L. defensins Rs-AFP1 and Rs-AFP2. The Ns-D1 and Ns-D2 defensins display strong although divergent antifungal activity towards a number of phytopathogenic fungi. High antifungal activity of N. sativa defensins makes them promising candidates for engineering pathogen-resistant plants.

• 出版日期2011-2