A Photolabile Linker for the Solid-Phase Synthesis of Peptide Hydrazides and Heterocycles

作者：Qvortrup Katrine; Komnatnyy Vitaly V; Nielsen Thomas E^*

来源：Organic Letters, 2014, 16(18): 4782-4785.

DOI：10.1021/ol502219s

A photolabile hydrazine linker for the solid-phase synthesis of peptide hydrazides and hydrazine-derived heterocycles is presented. The developed protocols enable the efficient synthesis of structurally diverse peptide hydrazides derived from the standard amino adds, including those with side-chain protected residues at the C-terminal of the resulting peptide hydrazide, and are useful for the synthesis of dihydropyrano[2,3-c]pyrazoles. The linker is compatible with most commonly used coupling reagents and protecting groups for solid-phase peptide synthesis.

• 出版日期2014-9-19