Novel and Efficient One-Pot Synthesis of (Aminophenyl)carbamic Acid Esters

作者:Garofalo Antonio; Goossens Laurence*; Six Perrine; Lebegue Nicolas; Depreux Patrick
来源:Synthetic Communications, 2011, 41(13): 2007-2016.
DOI:10.1080/00397911.2010.494818

摘要

[image omitted] A novel and efficient protocol is developed for the synthesis of various (aminophenyl)carbamic acid esters from the reduction and condensation of nitrophenyl isocyanate derivatives. The reaction takes place in various hydroxy derivatives such as alcohols or phenols under a hydrogen atmosphere using Raney nickel as catalyst. Products are obtained by a convenient one-pot synthesis with excellent yields and short reaction times.

  • 出版日期2011