Distribution of blaOXA-carrying imipenem-resistant Acinetobacter spp. in 3 hospitals in Taiwan

作者：Kuo Han Yueh; Yang Chih Man; Lin Ming Feng; Cheng Wen Lin; Tien Ni; Liou Ming Li^*

来源：Diagnostic Microbiology and Infectious Disease, 2010, 66(2): 195-199.

DOI：10.1016/j.diagmicrobio.2009.09.013

• Acinetobacter spp.
• Pulsed-field gel electrophoresis
• blaOXA-23 gene
• blaOXA-51 gene
• blaOXA-24 gene

We investigated the molecular epidemiology and OXA-type carbapenemase genes of 83 imipenem-resistant Acinetobacter spp. collected from 2 university hospitals (hospitals A and B) and a regional hospital (hospital C) during 2007 in Taiwan. Genotyping by pulsed-field gel electrophoresis identified 51 pulsotypes. None of the pulsotypes established predominance throughout the 3 hospitals. Multiplex polymerase chain reaction of blaOXA genes showed that 100% (18/18), 91%(31/34), and 100% (31/31) of the Acinetobacter spp. collected from hospital A, B, and C, respectively, possessed blaOXA-51 like genes. None of the strains carrying blaOXA-23 like and blaOXA-24 like genes were found in hospital A. The coexistences of blaOXA-51 like/blaOXA-23-like and blaOXA-51 like/blaOXA-24 like genes detected in hospitals B and C were 26% (9/34) and 12% (4/34) and 58% (18/31) and 3% (1/31), respectively. Among blaOXA-23 like gene-carrying isolates collected from hospitals, clonal spread of strains carrying the blaOXA-23 gene was detected in the regional hospital but not the other 2 university hospitals. The results suggest that interhospital dissemination of imipenem-resistant Acinetobacter spp. was not found in these hospitals. The increasing percentage of OXA-23 in OXA-type carbapenemases in Acinetobacter spp. from the regional hospitals to medical centers deserves further attention in Taiwan.

• 出版日期2010-2
• 单位中国医科大学