Association between a TGFBR2 Gene Polymorphism (rs2228048, Asn389Asn) and Acute Rejection in Korean Kidney Transplantation Recipients

作者：Kim Yeong Hoon; Kim Tae Hee; Kang Sun Woo^*; Kim Hyun Ju; Park Seok Ju; Jeong Kyung Hwan; Kim Su Kang; Lee Sang Ho; Ihm Chun Gyoo; Lee Tae Won; Moon Ju Young; Yoon Young Chul; Chung Joo Ho

来源：Immunological Investigations, 2013, 42(4): 285-295.

DOI：10.3109/08820139.2013.777073

• Rejection
• Polymorphism
• TGF-beta receptor II
• Kidney Transplantation

Transforming growth factor-beta (TGF-beta) signaling transduction initiates TGF-beta activation, resulting in activation of TGF-beta receptor II (TGFBR2). Any quantitative and qualitative changes in TGFBR2 are expected to affect the TGF-beta signaling pathway, which occupies a central position with respect to the regulation of cell growth, differentiation, apoptosis, immune reaction, angiogenesis and extracellular matrix formation. Recent studies have shown that TGF-beta 1 gene polymorphisms may confer susceptibility to early acute and chronic allograft rejection in kidney transplantation recipients. In this study, we assessed whether polymorphisms of the TGFBR2 gene were associated with susceptibility to kidney transplantation rejection. A total of 347 renal allograft recipients transplanted at three centers in Korea were analyzed. Three SNPs (rs764522, rs3087465, rs2228048) of the TGFBR2 gene were genotyped from genomic DNA with direct sequencing. Multiple logistic regression models (codominant, dominant, recessive, and logadditive) were performed to evaluate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. A total of 63 patients (18%) developed acute rejection (AR). There were no significant differences in age, sex, number of HLA mismatches, cause of renal failure, or immunosuppressant regimen between the AR and non-AR group. The synonymous SNP rs2228048 was significantly associated with AR (p = 0.020 in recessive model, and p = 0.036 in log-additive model. The allele frequencies of rs2228048 were different between the AR and non-AR group (p = 0.026). These results suggest that the synonymous TGFBR2 gene SNP rs2228048 may be associated with the development of AR in Korean kidney transplantation recipients.

• 出版日期2013