Associability-modulated loss learning is increased in posttraumatic stress disorder

作者：Brown, Vanessa M; Zhu, Lusha; Wang, John M; Frueh, B Christopher; King Casas, Brooks^*; Chiu, Pearl H^*

来源：eLife, 2018, 7: e30150.

DOI：10.7554/eLife.30150

Disproportionate reactions to unexpected stimuli in the environment are a cardinal symptom of posttraumatic stress disorder (PTSD). Here, we test whether these heightened responses are associated with disruptions in distinct components of reinforcement learning. Specifically, using functional neuroimaging, a loss-learning task, and a computational model-based approach, we assessed the mechanistic hypothesis that overreactions to stimuli in PTSD arise from anomalous gating of attention during learning (i.e., associability). Behavioral choices of combat-deployed veterans with and without PTSD were fit to a reinforcement learning model, generating trial-by-trial prediction errors (signaling unexpected outcomes) and associability values (signaling attention allocation to the unexpected outcomes). Neural substrates of associability value and behavioral parameter estimates of associability updating, but not prediction error, increased with PTSD during loss learning. Moreover, the interaction of PTSD severity with neural markers of associability value predicted behavioral choices. These results indicate that increased attention-based learning may underlie aspects of PTSD and suggest potential neuromechanistic treatment targets.

• 出版日期2018-1-7
• 单位美国弗吉尼亚理工大学(Virginia Tech); 北京大学