Phenytoin- and amlodipine-induced gingival overgrowth

作者：Chang Ching Wen; Yang Chih Jen; Lai Yu Lin^*

来源：Journal of Dental Sciences, 2012, 7(1): 85-88.

DOI：10.1016/j.jds.2012.01.013

• amlodipine
• drug-induced gingival overgrowth
• gingivectomy
• phenytoin

Drug-induced gingival overgrowth is an adverse event associated with three types of drugs, i.e., anticonvulsants, immunosuppressants, and calcium-channel blockers. It was shown that the combined use of an immunosuppressant (cyclosporine) and a calcium-channel blocker increases the prevalence and severity of gingival overgrowth. However, few reports discussed the effects of the combination of an anticonvulsant (phenytoin) and a calcium-channel blocker (amlodipine). In this case report, we present an epilepsy patient who was using both phenytoin and amlodipine, which caused extensive gingival overgrowth. After periodontal treatment and a gingivectomy, the gingival overgrowth was significantly reduced. A postoperative drug-substitution regimen and intensive professional care ensured a stable result 1 year after surgery.

• 出版日期2012-3