An efficient synthesis of iminoisoindolione derivatives by cobalt-catalyzed oxidative isocyanide insertion

作者：Zou, Feihua; Chen, Xuwen; Hao, Wenyan^*

来源：Tetrahedron, 2017, 73(6): 758-763.

DOI：10.1016/j.tet.2016.12.057

• Oxidative isocyanide insertion
• Cobalt-catalyzed
• Iminoisoindoliones
• Heterocycles
• C-H activation

A Cobalt-catalyzed oxidative isocyanide insertion of aminoquinoline benzamides has been developed. The reaction proceeded smoothly by using Ag2CO3 as the oxidant in PhCI at 120 degrees C and delivered products in moderate to excellent yields with excellent functional group tolerance. The transformation is supposed to undergo the ortho C-H activation and isocyanide insertion of C-Co species toward the benzamides. Attractive features of this system include the use of low cost cobalt catalyst, the easy-handling operation, and readily available substrates.

• 出版日期2017-2-9
• 单位江西师范大学