Dual Contrast - Magnetic Resonance Fingerprinting (DCMRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents

作者：Anderson Christian E; Donnola Shannon B; Jiang Yun; Batesole Joshua; Darrah Rebecca; Drumm Mitchell L; Brady Kalnay Susann M; Steinmetz Nicole F; Yu Xin; Griswold Mark A; Flask Chris A^*

来源：Scientific Reports, 2017, 7(1): 8431.

DOI：10.1038/s41598-017-08762-9

Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a single agent at a time. In this study, a new Dual Contrast - Magnetic Resonance Fingerprinting (DC - MRF) methodology is described that can detect and independently quantify the local concentration of multiple MRI contrast agents following simultaneous administration. This "multi-color" MRI methodology provides the opportunity to monitor multiple molecular species simultaneously and provides a practical, quantitative imaging framework for the eventual clinical translation of molecular imaging contrast agents.

• 出版日期2017-8-16