Antidepressant Medicine Use and Risk of Developing Diabetes During the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study

作者：Rubin Richard R^*; Ma Yong; Peyrot Mark; Marrero David G; Price David W; Barrett Connor Elizabeth; Knowler William C

来源：Diabetes Care, 2010, 33(12): 2549-2551.

DOI：10.2337/dc10.1033

OBJECTIVE - To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS)
RESEARCH DESIGN AND METHODS - DPP/DPPOS participants were assessed for diabetes every 6 months and for antidepressant use every 3 months in DPP and every 6 months in DPPOS for a median 10 0 year follow up
RESULTS - Controlled for factors associated with diabetes risk continuous antidepressant use compared with no use was associated with diabetes risk in the placebo (adjusted hazard ratio 2 34 [95% CI 1 32-4 15]) and lifestyle (2 48 [1 45-4 22]) arms but not in the metformin arm (0 55 [0 25-1 19])
CONCLUSIONS - Continuous antidepressant use was significantly associated with diabetes risk in the placebo and lifestyle arms Measured confounders and mediators did not account for this association which could represent a drug effect or reflect differences not assessed in this study between antidepressant users and nonusers

• 出版日期2010-12