Acute neuropathogenicity with experimental infection of equine herpesvirus 9 in common marmosets (Callithrix jacchus)

作者：Kodama A; Yanai T^*; Yomemaru K; Sakai H; Masegi T; Yamada S; Fukushi H; Kuraishi T; Hattori S; Kai C

来源：Journal of Medical Primatology, 2007, 36(6): 335-342.

DOI：10.1111/j.1600-0684.2007.00220.x

• Common marmosets
• encephalitis
• equine herpesvirus 9
• non-human primate

Background Equine herpesvirus 9 (EHV-9) is a new neurotropic equine herpesvirus which induced encephalitis in a variety of animals. However, there was no information on the susceptibility of EHV-9 in primates.
Methods To assess the infectivity of EHV-9, four common marmosets (Callithrix jacchus) were inoculated by the nasal route with 10(6) plaque-forming units of EHV-9.
Results and conclusions All of the inoculated animals exhibited various neurological signs progressing to collapse. Histologically, the affected animals had severe encephalitis characterized by neuronal degeneration and necrosis with intranuclear inclusion bodies, which extended from the olfactory bulb to the rhinencephalon and piriform lobe. Immunohistochemistry revealed EHV-9 antigens in degenerating neuronal cells. The nasal cavity had severe necrotizing rhinitis with prominent intra-nuclear inclusion bodies in the olfactory mucosa. These findings indicate that the marmosets are susceptible to EHV-9.

• 出版日期2007-12
• 单位河北医科大学