Autophagy: Can it become a potential therapeutic target? (Review)

作者：Bao Xiao Hong; Naomoto Yoshio^*; Hao Hui Fang; Watanabe Nobuyuki; Sakurama Kazufumi; Noma Kazuhiro; Motoki Takayuki; Tomono Yasuko; Fukazawa Takuya; Shirakawa Yasuhiro; Yamatsuji Tomoki; Matsuoka Junji; Takaoka Munenori

来源：International Journal of Molecular Medicine, 2010, 25(4): 493-503.

DOI：10.3892/ijmm_00000369

• autophagy
• protein and organelle degradation
• homeostasis
• protector
• physiological and pathological roles human diseases
• therapy

Autophagy is a cellular lysosomal degradation pathway involved in proteins and organelles recycling for promoting cell survival. development and homeostasis. It is a multistep process and genetic studies have identified many proteins that participate in autophagosome formation and fusion with lysosomes, and various singaling factors that associate with the regulation of autophagy. In general, autophagy acts as a cell protector and as dysfunction is correlated with diverse pathologies. well as neurodegeneration. liver, heart and muscle diseases. cancer. inflammation and ageing. However. its role in cell death Increases the complexity of to autophagic degradation system A broad understanding of autophagy. ranging From detailed processes. including induction, formation and degradation, to function m physiology and pathology. revealed by accumulating studies. may be helpful for formulating therapeutic strategies For autophagy-associated human diseases

• 出版日期2010-4