Secoiridoids from the stem barks of Fraxinus rhynchophylla with pancreatic lipase inhibitory activity

作者：Ahn Jong Hoon; Shin Eunjin; Liu Qing; Kim Seon Beom; Choi Kyeong Mi; Yoo Hwan Soo; Hwang Bang Yeon; Lee Mi Kyeong^*

来源：Natural Product Research, 2013, 27(12): 1132-1135.

DOI：10.1080/14786419.2012.711328

• Fraxinus rhynchophylla
• pancreatic lipase
• secoiridoid
• obesity

Pancreatic lipase digests dietary fats by hydrolysis, which is a key enzyme for lipid absorption. Therefore, reduction of fat absorption by the inhibition of pancreatic lipase is suggested to be a therapeutic strategy for obesity. From the EtOAc-soluble fraction of the stem barks of Fraxinus rhynchophylla (Oleaceae), four secoiridoids such as ligstroside (1), oleuropein (2), 2-hydroxyoleuropein (3) and hydroxyframoside B (4) were isolated. The inhibitory activity of these compounds on pancreatic lipase was assessed using porcine pancreatic lipase as an invitro assay system. Compound 4 showed the strongest inhibition on pancreatic lipase, which followed by compounds 1-3. In addition, compound 4 exerted inhibitory effect on pancreatic lipase in a mixed mechanism of competitive and noncompetitive manner. Taken together, F. rhynchophylla and its constituents might be beneficial to obesity.

• 出版日期2013-6-1