Assessment of Iron Distribution Between Liver, Spleen, Pancreas, Bone Marrow, and Myocardium by Means of R2 Relaxometry With MRI in Patients With beta-Thalassemia Major

作者：Papakonstantinou Olympia; Alexopoulou Efthymia; Economopoulos Nikos; Benekos Odysseas; Kattamis Antonis; Kostaridou Stavroula; Ladis Vasilis; Efstathopoulos Efstathios; Gouliamos Athanassios; Kelekis Nikolaos L^*

来源：Journal of Magnetic Resonance Imaging, 2009, 29(4): 853-859.

DOI：10.1002/jmri.21707

• thalassemia
• MRI
• R2 relaxometry
• iron overload

Purpose: To investigate the correlation between the degree of hepatic, splenic, pancreatic. vertebral bone marrow (VBM), and myocardial siderosis. as expressed by relaxation rate (R2 = 1/T2) values, in patients with thalassemia.
Materials and Methods: R2 relaxation rate values of liver, spleen, VBM, pancreas, and myocardium were estimated in 68 consecutive transfusion-dependent patients with beta-thalassemia major and 10 healthy controls using a respiratory triggered 16-echo Carr-Purcell-Melboom-Gill (CPMG) spin echo sequence.
Results: Hepatic R2 values were significantly Increased in all 68 patients; VBM, pancreatic, and myocardial R2 values were Increased in 67/68, 35/47, and 47/61 patients, whereas five patients showed decreased pancreatic R2 attributed to fatty degeneration. Of the 39 nonsplenectomized patients, splenic R2 values were decreased in 30 and normal in nine patients. Hepatic R2 values correlated with splenie (r = 0.63, P < 0.001), VBM (r = 0.52, P < 0.001), but not with myocardial and pancreatic R2 values.
Conclusion: Despite positive correlations between the degree of hepatic, splenic, and VBM siderosis, as expressed by respective R2 values, there was variability of Iron distribution patterns In thalassemic patients. Unpredictable parterns of iron distribution may be seen, such as normal signal of the spleen in the presence of siderotic liver, resembling primary hemochromatosis. Fatty degeneration of the pancreas was not uncommon.

• 出版日期2009-4