Nonlinear feedback drives homeostatic plasticity in H2O2 stress response

作者：Goulev Youlian^*; Morlot Sandrine; Matifas Audrey; Huang Bo; Molin Mikael; Toledano Michel B; Charvin Gilles^*

来源：eLife, 2017, 6: e23971.

DOI：10.7554/eLife.23971

Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell's ability to adapt to unanticipated environmental challenges. To bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases their resistance to subsequent threats. However, the mechanisms responsible for such adaptive homeostasis remain largely unknown. Here, we used live-cell imaging and microfluidics to investigate the adaptive response of budding yeast to temporally controlled H2O2 stress patterns. We demonstrate that acquisition of tolerance is a systems-level property resulting from nonlinearity of H2O2 scavenging by peroxiredoxins and our study reveals that this regulatory scheme induces a striking hormetic effect of extracellular H2O2 stress on replicative longevity. Our study thus provides a novel quantitative framework bridging the molecular architecture of a cellular homeostatic system to the emergence of nonintuitive adaptive properties.

• 出版日期2017-4-18
• 单位中国地震局