Structures and Biological Activities of Novel Biselyngbyaside Analogs Isolated from the Marine Cyanobacterium Lyngbya sp.

作者：Watanabe Ayane; Ohno Osamu; Morita Maho; Inuzuka Toshiyasu; Suenaga Kiyotake^*

来源：Bulletin of the Chemical Society of Japan, 2015, 88(9): 1256-1264.

DOI：10.1246/bcsj.20150117

Novel biselyngbyaside analogs, biselyngbyolide C (1) and biselyngbyasides E (2) and F (3), were isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The gross structures of 1-3 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. These compounds inhibited the growth of He La and HL60 cells. From the results of an MTT assay, the geometry of the trisubstituted olefin in the side chain and the lack of the sugar moiety were found to be important for the biological activity. In addition, 1 was found to exhibit ER stress- and apoptosis-inducing activities in He La cells.

• 出版日期2015-9-15