Angiotensin-(1-7) improves non-alcoholic steatohepatitis through an adiponectin-independent mechanism

作者：Tang, Ailian; Li, Can; Zou, Nan; Zhang, Qian; Liu, Meiling; Zhang, Xia^*

来源：Hepatology Research, 2017, 47(1): 116-122.

DOI：10.1111/hepr.12707

• adiponectin
• AMPK
• non-alcoholic steatohepatitis

AimRecent evidence suggests that angiotensin-(1-7) [Ang-(1-7)] could improve non-alcoholic steatohepatitis (NASH) through an adiponectin-dependent mechanism. This study aimed to investigate whether and how Ang-(1-7) influences NASH without adiponectin. @@@ MethodsAdiponectin knockout mice were fed with a high fat diet (HFD) or normal chow for 6months, and were subsequently infused with Ang-(1-7) or saline for 2weeks. @@@ ResultsWe found that HFD-fed mice showed obesity, hyperlipidemia, NASH, and significantly increased levels of serum Ang-(1-7). Chronic infusion of Ang-(1-7) could reduce body weight, absolute and relative liver weight, and serum levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in HFD-fed mice. In addition, Ang-(1-7) treatment could attenuate hepatocellular inflammation, steatosis, and ballooning with activation of the hepatic AMP-activated protein kinase signaling pathway in HFD-fed knockout mice. @@@ ConclusionsThese results showed the protective role of Ang-(1-7) in the development of NASH through an adiponectin-independent mechanism, which may be partially attributed to the activation of hepatic AMP-activated protein kinase pathway.

• 出版日期2017-1
• 单位重庆医科大学