Allogeneic stem cell transplantation for chronic myelomonocytic leukemia: a report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire

作者：Park Sophie^*; Labopin Myriam; Yakoub Agha Ibrahim; Delaunay Jacques; Dhedin Nathalie; Deconinck Eric; Michallet Mauricette; Robin Marie; De Revel Thierry; Bernard Marc; Vey Norbert; Lioure Bruno; Lapusan Simona; Tabrizi Reza; Bourhis Jean Henri; Huynh Anne; Beguin Yves; Socie Gerard; Dreyfus Francois; Fenaux Pierre; Mohty Mohamad

来源：European Journal of Haematology, 2013, 90(5): 355-364.

DOI：10.1111/ejh.12073

• allotransplantation
• chronic myelomonocytic leukemia
• myelodysplastic
• splenomegaly

Objectives and methods Chronic myelomonocytic leukemia (CMML) is a severe disease for which allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative treatment. We describe a retrospective study determining prognostic factors for outcome after allo-SCT in consecutive 73 patients with CMML reported to the SFGM-TC registry between 1992 and 2009. Results At diagnosis, median age was 53yrs, and 36% patients had palpable splenomegaly (SPM). 48, 13, and 9 patients had good, intermediate, and poor risk karyotype, respectively, according to IPSS, 61% patients had CMML-1, and 39% had CMML-2. 41/31/1 cases had an HLA-identical sibling, an unrelated and haploidentical donor, respectively. 43 patients received reduced-intensity conditioning. With a median follow-up of 23month, acute grade 24 and chronic GVHD developed in 21 and 25 patients, respectively. The 3-year OS, NRM (non-relapse mortality),EFS, and CIR (cumulative incidence of relapse) were 32%, 36%, 29% and 35%, respectively. OS was not influenced by the CR status, marrow blasts% at allo-SCT, prior treatments, and cGVHD. Using multivariate analysis, year of transplant%26lt;2004 (YOT) (P=0.005) was associated with higher NRM, YOT%26lt;2004 (P=0.04) and SPM at allo-SCT (P=0.02) with lower EFS, and YOT%26lt;2004 (P=0.03) and SPM at allo-SCT (P=0.04) with poorer OS. Conclusions Allogeneic stem cell transplantation is a valid treatment option for patients with CMML, and its outcome has improved with YOT%26gt;2004. Splenomegaly seems to be a negative factor of OS and EFS in this series.

• 出版日期2013-5