Amberlite IR-120H as an efficient and versatile solid phase catalyst for nucleophilic substitution of propargylic alcohols

作者：Gujarathi Satheesh; Hendrickson Howard P; Zheng Guangrong^*

来源：Tetrahedron Letters, 2013, 54(27): 3550-3553.

DOI：10.1016/j.tetlet.2013.04.120

• Amberlite IR-120H
• Nucleophilic substitution
• Propargylic alcohols
• Solid phase catalyst
• Regioselectivity

A highly efficient Amberlite IR-120H resin mediated nucleophilic substitution of the hydroxyl group of propargylic alcohols with a wide range of nucleophiles is reported. The reactions were achieved under very mild conditions in excellent yields.

• 出版日期2013-7-3