Modification of vascular and inflammation biomarkers after OGTT in overweight healthy and diabetic subjects

作者：Derosa Giuseppe^*; D'Angelo Angela; Salvadeo Sibilla A T; Ferrari Ilaria; Fogari Elena; Gravina Alessia; Mereu Roberto; Palumbo Ilaria; Maffioli Pamela; Randazzo Sabrina; Cicero Arrigo F G

来源：Microvascular Research, 2010, 79(2): 144-149.

DOI：10.1016/j.mvr.2010.01.002

• Type 2 diabetes mellitus
• OGTT
• Endothelial stress
• Metalloproteinases
• Vascular remodelling

We evaluated the effect of all oral glucose tolerance test (OGTT) oil the level of biomarkers of vascular remodelling We enrolled 256 Caucasian overweight healthy subjects (H) and 274 overweight type 2 diabetic patients (D) All patients underwent basal measurements of blood glucose (BG), nitrites/nitrates, adiponectin (ADP), matrix metalloproteinase-2 (MMP-2). and matrix metalloproteinase-9 (MMP-9) before and after OGTT Nitrites/nitrates decrease was present after 60, 90, 120, and 180 min ill both groups Nitrite/nitrate levels were decreased at baseline, after 30 and 60 min in D group compared to H group ADP decrease was present after 90, 120, and 180 min, in both groups ADP levels were lower in D group than in H group during OGTT MMP-2 increase was present after 60, 90, and 120 min in H group, while MMP-2 increase was observed after 90, 120, and 180 min in D group MMP-2 levels were higher in D group than in H group during OGTT MMP-9 increase was present in H group after 60, 90, 120. and 180 min. while MMP-9 increase was observed after 90, 120, and 180 min in

• 出版日期2010-3