Systemic Lupus and Risk of Restless Legs Syndrome

作者：Hassan Noura; Pineau Christian A; Clarke Ann E; Vinet Evelyne; Ng Ryan; Bernatsky Sasha^*

来源：Journal of Rheumatology, 2011, 38(5): 874-876.

DOI：10.3899/jrheum.101039

• SYSTEMIC LUPUS ERYTHEMATOSUS
• RESTLESS LEGS SYNDROME
• OBESITY

Objective. To determine the prevalence of restless legs syndrome (RLS) in women with systemic lupus erthythematosus (SLE), and to compare this to a rheumatic disease sample without SLE.
Methods. Unselected consecutive female patients were SLE were recruited from a lupus clinic. A RLS questionnaire based on 4 criteria, validated by the International Restless Legs Syndrome Study Group, was administered during a face-to-face interview. Smoking history and height and weight data were collected. Similar methods were used to determine RLS prevalence in a comparator group of women with rheumatic diseases other than SLE. Controls were frequency-matched by age group (in 5-year age bands) to SLE subjects. Controls were otherwise unselected.
Results. We recruited 33 women with SLE and 32 controls. Twelve of 33 female SLE subjects scored positively for RLS (37.5%; 95% CI 22.9, 54.7) compared to 4 of 32 controls (12.5%; 95% CI 5.0, 28.1). Multivariate logistic regression showed that adjusted for age, obesity, and smoking, women with SLE were more likely to have RLS than the female controls (adjusted odds ratio 6.61, 95% CI 1.52, 28.77). In our multivariate analyses of all rheumatic patients, including SLE, the adjusted OR for obesity and RLS was 5.14 (95% CI 1.07, 24.6).
Conclusion. These novel data indicate that RLS is more prevalent in women with SLE than in controls. Although obesity was a significant risk factor for RLS in our sample, the predictive covariates examined were limited. (First Release Feb 15 2011; J Rheumatol 2011;38:874-6; doi:10.3899/jrheum.101039)

• 出版日期2011-5