Pathogenic Yersinia DNA in Intestinal Specimens of Pediatric Patients with Crohn's Disease

作者：Leu Sarah B; Shulman Sarah Catherine; Steelman Charlotte Katherine; Lamps Laura W; Bulut Ozlem P; Abramowsky Carlos R; Gold Benjamin D; Szlam Sarah; Stockwell Christina; Havens Jennifer; Kolta Soha; Shehata Bahig M^*

来源：Fetal and Pediatric Pathology, 2013, 32(5): 367-370.

DOI：10.3109/15513815.2013.768744

• crohn's disease
• inflammatory bowel disease
• yersinia

Studies indicate a close relationship between Yersinia and Crohn's disease in adults. Our study tested 77 colonic specimens from children with Crohn's disease for the presence of Yersinia DNA using a validated polymerase chain reaction (PCR) assay. Control cases included specimens from 45 ulcerative colitis patients and 10 appendicitis patients. The presence of Yersinia in Crohn's specimens was significant compared to the control specimens (9% vs. 0%; p=0.0055). While our study supports the medical literature, future studies are needed to determine if the relationship between Crohn's disease and Yersinia is an initiating or mediating factor in the pathogenesis of pediatric Crohn's disease.

• 出版日期2013