科研之友
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摘要
Background: We describe the clinical course of one industrial technician occupationally exposed to nickel carbonyl (NiC).Case report: A 50-year-old male industrial technician presented with complaints of nausea, myalgia, and cough to a local clinic after suspected occupational exposure to nickel carbonyl. He has no history of lung disease or smoking. His initial urine nickel concentration was 692 ug/L. He had infiltrates on the initial chest X-ray (CXR) and an oxygen saturation (O-2) of 97% on room air. The patient was started on disulfiram 1g by mouth (PO), 500mg six hours after the first dose, then 250mg twice daily for five days with prednisone 60mg by mouth for five days. He presented 48hours later with worsening respiratory symptoms. His O-2 saturation decreased to 85% despite two days of oral steroids, and he was admitted to a hospital. He received prednisone 60mg/day PO, 4L nasal O-2, and disulfiram 500mg twice daily. He was discharged on day 7 post-exposure with disulfiram and prednisone.Case discussions: NiC is a severe respiratory irritant. Disulfiram was used off-label and was based on an established company protocol.Conclusions: Inhalation exposure to NiC resulted in a delayed respiratory dysfunction which responded to disulfiram treatment.
- 出版日期2018
