Asymmetric dimethylarginine is related to the predicted stroke risk in middle-aged Japanese men

作者：Nishiyama Yasuhiro^*; Otsuka Toshiaki; Ueda Masayuki; Inagaki Hirofumi; Muraga Kanako; Abe Arata; Kawada Tomoyuki; Katayama Yasuo

来源：Journal of the Neurological Sciences, 2014, 338(1-2): 87-91.

DOI：10.1016/j.jns.2013.12.021

• Dimethylarginine
• Stroke
• Japanese middle-aged men
• Risk factors
• Cross-sectional study
• Male

Background: Asymmetric dimethylarginine (ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, whether ADMA levels are related to the risk of stroke in the Japanese general population remains unclear.
Methods: We examined 769 Japanese men (mean age, 47 5 years) undergoing health examinations. Each subject's ADMA level and various vascular risk factors were assessed; the predicted 10-year stroke risk was calculated using the point-based prediction model from the Japan Public Health Center Study.
Results: In a multiple linear regression analysis, age, body mass index, estimated glomerular filtration rate, and current smoking status were significant independent determinants of ADMA levels. A significant odds ratio (OR) for high predicted stroke risk (10-year risk >= 5%)was noted in the highest quartile of ADMA levels (OR, 2.47; 95% CI, 1.002-6.07), compared with the lowest quartile, after adjusting for potential confounding factors. A significant OR for high predicted stroke risk was also found for each standard deviation increment in ADMA level (adjusted OR, 1.46; 95% CI, 1.10-1.92).
Conclusion: Elevated ADMA levels were significantly associated with an increased predicted stroke risk, suggesting that measuring ADMA levels may be useful for identifying middle-aged Japanese men with a high risk of stroke.

• 出版日期2014-3-15