Huangqiyenins G-J, Four New 9,10-Secocycloartane (=9,19-Cyclo-9,10-secolanostane) Triterpenoidal Saponins from Astragalus membranaceus Bunge Leaves

作者：Kuang, Hai-Xue^*; Wang, Qiu-Hong; Yang, Bing-You; Wang, Zhi-Bin; Okada, Yoshihito; Okuyama, Tohru

来源：Helvetica Chimica Acta, 2011, 94(12): 2239-2247.

DOI：10.1002/hlca.201100174

• Astragalus membranaceus
• Triterpenoid saponins
• Huangqiyenins G?-?J
• Saponins

Four new 9,10-secocycloartane (=9,19-cyclo-9,10-secolanostane) triterpenoidal saponins, named huangqiyenins GJ (14, resp.), were isolated from Astragalus membranaceus Bunge leaves. The acid hydrolysis of 14 with 1M aqueous HCl yielded D-glucose, which was identified by GC analysis after treatment with L-cysteine methyl ester hydrochloride. The structures of 14 were established by detailed spectroscopic analysis as (3 beta,6a,10a,16 beta,24E)-3,6-bis(acetyloxy)-10,16-dihydroxy-12-oxo-9,19-cyclo-9,10-secolanosta-9(11),24-dien-26-yl beta-D-glucopyranoside (1), (3 beta,6a,10a,24E)-3,6-bis(acetyloxy)-10-hydroxy-12,16-dioxo-9,19-cyclo-9,10-secolanosta-9(11),24-dien-26-yl beta-D-glucopyranoside (2), (3 beta,6a,9a,10a,16 beta,24E)-3,6-bis(acetyloxy)-9,10,16-trihydroxy-9,19-cyclo-9,10-secolanosta-11,24-dien-26-yl beta-D-glucopyranoside (3), and (3 beta,6a,10a,24E)-3,6-bis(acetyloxy)-10-hydroxy-16-oxo-9,19-cyclo-9,10-secolanosta-9(11),24-dien-26-yl beta-D-glucopyranoside (4).

• 出版日期2011-12
• 单位黑龙江中医药大学